# TRABECULAR ARCHITECTURAL EFFECTS ON MATERIAL PROPERTIES

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1991 · $172,850

## Abstract

The objective of this project is to investigate the relationship between
the morphologic and architectural configuration of trabecular bone and its
mechanical properties. During the first phase of investigation, we have
developed the capabilities of quantifying three-dimensional morphology,
connectivity, and anisotropy of trabecular bone samples utilizing a unique
microcomputed tomography scanner. In addition, we have experimentally
derived an empirical relationship between orthogonal moduli and trabecular
morphology.

The specific aims of this proposal are:

1. To validate and evaluate the use of a new three-dimensional morphologic
and structural algorithm which we have designated the "configuration
method".
2. To experimentally develop a more generalized structure function
relationship for human trabecular bone in order to predict the Young's and
shear moduli from morphologic and architectural measures.
3. To experimentally determine the variation in trabecular tissue moduli as
a function of age and anatomic location.
4. Utilize a microstructural approach to analytically and experimentally
investigate the optimality of trabecular structure and perform a
sensitivity analysis on the morphologic and architectural factors that
contribute to mechanical integrity.

The project will involve measuring the trabecular bone morphology and
architecture utilizing microcomputed tomography scanning, continuum level
materials testing, and microstructural materials testing. The analtyical
procedures will include finite element based optimization algorithms along
with of homogenization theory.

The results of these studies will provide evidence for trabecular bone
remodeling strategies related to structural optimization. This information
will support continuing efforts towards understanding relationships between
physiologic, mechanical, or environmental alterations and trabecular bone.

## Key facts

- **NIH application ID:** 3156834
- **Project number:** 5R01AR034399-06
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** Steven A Goldstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $172,850
- **Award type:** 5
- **Project period:** 1986-08-01 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156834

## Citation

> US National Institutes of Health, RePORTER application 3156834, TRABECULAR ARCHITECTURAL EFFECTS ON MATERIAL PROPERTIES (5R01AR034399-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156834. Licensed CC0.

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