# B CELL HYPERACTIVITY IN AUTOIMMUNITY

> **NIH NIH R01** · BOSTON UNIVERSITY MEDICAL CAMPUS · 1989 · $177,831

## Abstract

The purpose of the proposed study is to delineate the basic
immunological mechanisms responsible for B cell hyperactivity in
the autoimmune MRL/1pr mouse model.  The major goals of this
proposal will be to examine the direct effect of the 1pr mutation
on specific B cell lineages, to assess the relative roles of
polyclonal activation and antigen specific activation in driving
autoantibody production, and to determine the pathogenic and
immunoregulatory effects of rheumatoid factors on the 1pr disease
process.  The specific approaches that will be used to address
these issues will include:  the production of chimeric mice
expressing the 1pr mutation in which the development and functional
activity of B cells derived from a mixture of normal and autoimmune
stem cells will be monitored; the molecular analysis of B cells
committed to the production of a crossreactive idiotype following
immunization with specific hapten in the context of an autoimmune
1pr environment; the characterization of the in vivo and in vitro
proliferative capacity of B cell clones associated with monoclonal
gammapathies in 1pr mice; the assessment of the ability of
passively transferred monoclonal rheumatoid factors to cause
nephritis in mice with preformed IgG2a antibody in normal and
autoimmune mice injected at a young age.  Overall these studies
should contribute to our basic understanding of the mechanisms
regulating B cell activation and antibody production.  The results
of this proposal should eventually have clinical application with
regard to the control of the basic immunoregulatory defects
involved in autoimmune disorders such as systemic lupus
erythematosus and rheumatoid arthritis.

## Key facts

- **NIH application ID:** 3157118
- **Project number:** 2R01AR035230-04
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **SAM.gov UEI:** FBYMGMHW4X95
- **Principal Investigator:** Ann Marshak-Rothstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $177,831
- **Award type:** 2
- **Project period:** 1986-09-22 → 1994-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157118

## Citation

> US National Institutes of Health, RePORTER application 3157118, B CELL HYPERACTIVITY IN AUTOIMMUNITY (2R01AR035230-04). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3157118. Licensed CC0.

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