# ANALYSIS OF RHEUMATOID ARTHRITIS SUSCEPTIBILITY

> **NIH NIH R01** · HOSPITAL FOR JOINT DISEASES ORTHO INST · 1989 · $336,621

## Abstract

The proposed studies will explore the possibility that specific polymorphic
epitopes on Ia molecules play a major role in determining susceptibility to
rheumatoid arthritis as evidenced by the association with DR4.  Underlying
this project is the hypothesis that Ia molecules themselves have an
intermediary role, and that the functionally important components of the
molecule are specific epitopes.  The question of the meaning of
DR4-negative rheumatoid arthritis patient will be addressed and the
possibility explored tht certain disease related epitopes on Ia molecules
of these individuals are shared with molecules encoded by the specific DR4
haplotypes associated with RA.  Moreover, how these epitopes are expressed
and function will begin to be approached in individuals with rheumatoid
arthritis as well as by using T cell hybridomas and clones.  Extensive
reliance will be placed on the interrelated techniques of molecular
immunology and molecular biology to gain detailed insight into the relation
between the complexity of the Ia system and susceptibility to rheumatoid
arthritis.  The resulting information will be applied to continuing studies
on rheumatoid arthritis patients in an effort to more fully understand its
significance in clinical terms and in better delineating the exact role of
certain immunologic alterations in the pathogenesis of rheumatoid arthritis.

## Key facts

- **NIH application ID:** 3157173
- **Project number:** 5R01AR035404-05
- **Recipient organization:** HOSPITAL FOR JOINT DISEASES ORTHO INST
- **Principal Investigator:** Robert J Winchester
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $336,621
- **Award type:** 5
- **Project period:** 1985-07-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157173

## Citation

> US National Institutes of Health, RePORTER application 3157173, ANALYSIS OF RHEUMATOID ARTHRITIS SUSCEPTIBILITY (5R01AR035404-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3157173. Licensed CC0.

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