# BONE FORMATION AND MINERALIZATION:  STUDIES ON ALUMINUM

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1988 · $77,219

## Abstract

Osteomalacia is a process whereby the mineralization of bone is impaired.
Aluminum has been implicated as a cause of this clinical disorder, but the
mechanism by which aluminum induces a defect in the mineralization of bone
has yet to be established.  The osteomalacia associated with aluminum
deposition in bone is a disease model of particular interest because
defective mineralization of bone occurs despite normal concentrations of
calcium and phosphorus in serum.  It is the purpose of this proposal to
study the formation and mineralization of bone in the presence and absence
of aluminum using in vitro tissue culture techniques.  The putative actions
of aluminum as an inhibitor of the synthesis of new bone collagen and as a
physical-chemical inhibitor of mineralization will be evaluated.  The
response of bone tissues to parathyroid hormone and to 1,25
dihydroxyvitamin D will also be studied to investigate the role of
alterations in the response of bone to these hormones during exposure to
aluminum as potential mechanisms to explain the skeletal toxicity of
aluminum.

The results of the proposed studies should further our understanding of the
processs of bone matrix formation and calcification and how these are
altered by exposure to aluminum.  Such investigations are relevant to the
clinical bone disease observed in patients with chronic renal failure who
currently are exposed to aluminum as part of their therapeutic regimen.

## Key facts

- **NIH application ID:** 3157200
- **Project number:** 5R01AR035470-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** WILLIAM G GOODMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $77,219
- **Award type:** 5
- **Project period:** 1986-02-01 → 1989-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157200

## Citation

> US National Institutes of Health, RePORTER application 3157200, BONE FORMATION AND MINERALIZATION:  STUDIES ON ALUMINUM (5R01AR035470-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3157200. Licensed CC0.

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