# HUMAN IMMUNE COMPLEX DISEASES

> **NIH NIH R01** · LAHEY CLINIC · 1989 · $157,122

## Abstract

Previous work on the role of immune complexes in the
pathogenesis of systemic lupus erythematosus (SLE), rhematoid
arthritis and related disorders will be continued.  In studies on
RA, mixed connective tissue disease and essential mixed
cryoglobulinemia (EMC), the role of rheumatoid factors with BLA
and WA cross idiotypes (XIds) will be investigated.  Polyclonal
RFs bearing the BLA XId appear to occur in high incidence in
rheumatoid arthritis while those bearing the WA XId occur widely
in EMC and primary Sjogren syndrome.  The BLA group of RFs are
unique in reacting with DNA nucleoprotein in addition to IgG.  In
RA emphasis will be placed on characterization of immune
complexes containing BLA RFs.  Using sensitive immunoblotting
techniques non-IgG antigen cross reactive with RF and
antiidiotype antibodies will be sought.  Similar studies will be
done on the cryoglobulin from patients with EMC and the
hypothesis will be tested that antiidiotype antibody is involved in
the pattern of early complement component activation seen in
this disease.  Newly developed mouse monoclonal anti WA XId and
anti WA Id will be used on a model system in these studies.  In
SLE the primary emphasis will be on studying the serum low
molecular weight Clq reactants to determine their relationship to
the associated hypocomplementemia and antibodies to native
DNA that occurs in patients with these reactants.  New attempts
will be made to develop an anti native DNA XId antibody that
reacts only with nDNA antibodies.  Such a reagent would
markedly facilitate these studies.

## Key facts

- **NIH application ID:** 3157213
- **Project number:** 5R01AR035487-05
- **Recipient organization:** LAHEY CLINIC
- **SAM.gov UEI:** MWCKAJN2TQJ7
- **Principal Investigator:** Vincent Agnello
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $157,122
- **Award type:** 5
- **Project period:** 1984-09-01 → 1992-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157213

## Citation

> US National Institutes of Health, RePORTER application 3157213, HUMAN IMMUNE COMPLEX DISEASES (5R01AR035487-05). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3157213. Licensed CC0.

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