# VIRUS-INDUCED IMMUNOPATHOLOGY

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 1987 · $81,010

## Abstract

Mice receiving i.p. vaccinia virus (VV) infection after recovery from
lymphocytic choriomeningitis virus (LCMV) infection become clinically ill,
a condition not caused by either virus alone.  Histological examination of
the sick mice reveals no abnormalities except for an extensive macrophage
and lymphocyte infiltration of adipose tissue and for large necrotic areas
in pelvic, mesenteric, and perirenal fat.  This may be a model for
Weber-Christian disease as well as a model for unique immunopathology
resulting from sequential infections with two antigenically unrelated
viruses.

Experiments are designed to examine viral replication in adipocytes and to
determine if latent viruses are activated by the infection sequence.  The
local immune response in the peritoneum will be analyzed.  A protocol for
adoptive transfer of leukocytes into cyclophosphamide-treated mice is
outlined to examine the nature of the effector cell as well as target cell
requirements.  Primary adipocyte cultures will be examined for
susceptibility to cytotoxic T cells.  Adipocytes will be exposed to IFN in
vivo and in vitro to determine if it renders them more sensitive to CTL by
examining expression of histocompatibility antigens.

## Key facts

- **NIH application ID:** 3157227
- **Project number:** 5R01AR035506-03
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **SAM.gov UEI:** MQE2JHHJW9Q8
- **Principal Investigator:** Raymond M Welsh
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $81,010
- **Award type:** 5
- **Project period:** 1985-04-01 → 1988-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157227

## Citation

> US National Institutes of Health, RePORTER application 3157227, VIRUS-INDUCED IMMUNOPATHOLOGY (5R01AR035506-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3157227. Licensed CC0.

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