# VIRUS-INDUCED IMMUNOPATHOLOGY

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 1990 · $139,984

## Abstract

Virus-induced stimulation of T cell responses will be examined in mice
infected with either of several viruses, including lymphocytic
choriomeningitis, murine cytomegalo, vaccinia, Pichinde, and influenza
viruses.  Virus-induced stimulation of allospecific cytotoxic T cells (CTL)
in C57BL/6 mice will be examined in regard to target specificity, genetic
requirements for induction, relationship with other CTL, and regulation by
soluble factors.  The T cell receptors of virus-specific CTL, virus-induced
allospecific CTL, and conventionally induced allospecific CTL will be
compared.  Similarly, in a second model of polyclonal CTL induction by
viruses, the activation of virus specific memory CTL by infections with
antigenically distinct viruses will be examined.  In certain sequences of
virus infection a disease results which neither virus alone would normally
induce.  This is associated with mononuclear cell infiltration and necrosis
of visceral fat.  The cellular responses associated with this necrosis will
be identified and correlated to the property of the acute virus infections
to polyclonally activate CTL.  In man, virus infections have been
associated with allograft rejections, tumor remissions, and development of
autoimmunity.  Studying the mechanism of virus-induced polyclonal CTL
stimulation may help in the understanding of these potent pathological
sequelae of virus infections.

## Key facts

- **NIH application ID:** 3157228
- **Project number:** 5R01AR035506-05
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **SAM.gov UEI:** MQE2JHHJW9Q8
- **Principal Investigator:** Raymond M Welsh
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $139,984
- **Award type:** 5
- **Project period:** 1989-06-15 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157228

## Citation

> US National Institutes of Health, RePORTER application 3157228, VIRUS-INDUCED IMMUNOPATHOLOGY (5R01AR035506-05). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3157228. Licensed CC0.

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