# RISK FACTORS FOR HIP AND COLLES' FRACTURES

> **NIH NIH R01** · KAISER FOUNDATION RESEARCH INSTITUTE · 1991 · $584,774

## Abstract

Fractures of the hip and wrist are a costly and preventable threat to the
health and survival of the elderly.  A better understanding of the risk
factors for hip and Colles' fractures will add to our knowledge about the
etiology of this condition and help focus research and preventive efforts
on those who are at greatest risk.

We propose to characterize risk factors for hip and Colles' fractures in a
multicenter prospective study of 9,600 elderly women followed quarterly for
an average of 3.5 years.  Our cohort will be a population-based sample of
non-black women aged 65 or greater who are screened from 1986 thru 1988 at
clinical centers in Pittsburgh, Portland, Maryland and Minneapolis.

The Portland Clinical Center will attempt to recruit its entire sample from
the membership of Kaiser Permanente, Northwest Region.  The Center for
Health Research has access to all medical of the KP membership and has
extensive experience in recruitment and follow-up of large populations.

At the baseline exam, we will measure a large set of potential historical
and clinical predictors of fractures.  We will use single-photon
absorptiometry of the radius and also x-ray the hand, spine and hips to
determine whether simple radiographic measurements can identify those with
the greatest risk of fracture.  We will also freeze serum from all
participants at the outset and test the stability of hormone measurements
on a subsample after storage at -196 degrees C for several years;
measurements that are shown to be stable will be the subject of a future
study of the hormonal differences between women who suffer fractures and
those who do not.  We conservatively estimate that 165 hip and 150 Colles'
fractures will occur, yielding a power of .90 to detect risk ratios of less
than 2.0 for common risk factors.

Our prospective design will yield more information with fewer biases than
the previous (retrospective) studies on this topic, and our nested-case
control analyses will minimize the costs of the expensive endocrinologic
and radiologic measurements.  The study cohort, and its bank of sera,
x-rays and clinical data is an excellent resource for future studies of
osteoporosis, fractures and other diseases of the elderly.  The results of
our study will guide future research and rationalize clinical and public
health efforts to prevent these fractures.

## Key facts

- **NIH application ID:** 3157269
- **Project number:** 5R01AR035583-06
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** THOMAS MICHAEL VOGT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $584,774
- **Award type:** 5
- **Project period:** 1986-02-01 → 1992-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157269

## Citation

> US National Institutes of Health, RePORTER application 3157269, RISK FACTORS FOR HIP AND COLLES' FRACTURES (5R01AR035583-06). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3157269. Licensed CC0.

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