# MUSCLE SATELLITE CELL:  REACTION TO DISEASE AND TRAUMA

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1988 · $105,140

## Abstract

It is proposed to study in depth, the muscle satellite cells, with emphasis on
the following objectives:  1.  The morphology and distribution of satellite
cells in neonatal muscle.  2.  Determination of the effect of pathologic
processes and trauma (dystrophy and denervation) on the quantity and
ultrastructure of muscle satellite cells.  3.  Comparison of satellite cell
dynamics in myogenesis and growth of dystrophic and normal muscle.  4.
Investigation of the origin and fate of satellite cells in degenerating and
regenerating muscle.  5.  Analysis of the significance of the satellite cell in
muscular dystrophy.
In vivo studies of two genetic mutant mouse strains (C57BL/6J-dy2J and
129/Re-dy) will be carried out using light and electron microscopy and light
microscopic radioautography.

## Key facts

- **NIH application ID:** 3157538
- **Project number:** 5R01AR036294-12
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **SAM.gov UEI:** MKAGLD59JRL1
- **Principal Investigator:** Marcia R. Ontell
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $105,140
- **Award type:** 5
- **Project period:** 1986-01-01 → 1988-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157538

## Citation

> US National Institutes of Health, RePORTER application 3157538, MUSCLE SATELLITE CELL:  REACTION TO DISEASE AND TRAUMA (5R01AR036294-12). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3157538. Licensed CC0.

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