# MUSCLE SATELLITE CELL:  REACTION TO DISEASE AND TRAUMA

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1991 · $158,297

## Abstract

It is proposed to study, in depth, genetically determined myopathies,
with particular emphasis on the following objectives;
1. Elucidation of the mechanism(s) responsible for determining whether
genetically dystrophic (dy) murine muscle expresses or fails to express
the dystrophic phenotype.

2. Determination of whether the inhibition of the degeneration-
regeneration cycle which occurs when dystrophic (dy) muscle is
transiently denervated is unique to this dystrophic mutant or whether a
similar modification will occur in other diverse genetically determined
myopathies (e.g., the mdx mouse and the dystrophic hamster).

3. Determination of the effect of inhibition of the degeneration-
regeneration cycle of dystrophic (dy) myofibers on the development of
proliferative senescence of myosatellite cells of these muscles.
Determination whether the proliferative senescence of dy myosatellite
cells in vitro is a result of the exhaustion of the mitotic capability of
these cells during the early stage of the disease process or whether
there is a primary defect in the myosatellite cells of dy muscles.

4. Evaluation of the extent of regeneration which occurs in the mdx
mutant mouse. Evaluation of the mitotic capability of the myosatellite
cells of the mdx muscle using clonal analysis.

## Key facts

- **NIH application ID:** 3157540
- **Project number:** 5R01AR036294-15
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **SAM.gov UEI:** MKAGLD59JRL1
- **Principal Investigator:** Marcia R. Ontell
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $158,297
- **Award type:** 5
- **Project period:** 1986-01-01 → 1992-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3157540

## Citation

> US National Institutes of Health, RePORTER application 3157540, MUSCLE SATELLITE CELL:  REACTION TO DISEASE AND TRAUMA (5R01AR036294-15). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3157540. Licensed CC0.

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