# PHARMACOLOGICALLY INDUCED NEO-OSTEOGENESIS

> **NIH NIH R01** · DUKE UNIVERSITY · 1993 · $253,118

## Abstract

DESCRIPTION:  (Adapted from investigator's abstract) Potent trophic effects
of aluminum on bone have recently been identified in the investigator's
laboratory.  In this regard, aluminum substantially increases bone density
and volume in normal beagles due to an uncoupling of bone remodeling and de
novo bone histogenesis within the marrow cavity.  These pharmacologic
skeletal effects are unprecedented and may provide a means whereby new
three-dimensional trabecular structures can be generated.

The long-term objective of this proposal is to understand the mechanism(s)
of this unique osteoinductive action.  In pursuit of this goal, the effect
of aluminum to stimulate bone formation will be further characterized in
vivo and the potential to induce mitogenesis in cell culture systems will
be explored.

The specific aims of the animal studies are to confirm the time course of
aluminum-induced osteogenesis in trabecular bone and to examine the effects
of aluminum on cortical bone; to determine if the resultant woven bone
remodels, persists after the cessation of aluminum treatment, and imparts
structural integrity to bone; and to identify whether this agent can
restore bone in osteopenic models.  The in vitro studies will:  (1)
determine if this osteoinductive action is indirectly mediated through the
release of paracrine factors from monocytes; and (2) test for potential
direct actions of aluminum, explore the interrelationships between aluminum
and specific endogenous growth factors and/or exogenous mitogen, and
determine the influence of cell differentiation on aluminum action using
cell culture systems of osteoblasts and mesenchymal precursors.
Information obtained from these studies will likely lead to a better
understanding of a novel agent(s) with osteogenic potential and may be
useful in designing effective therapy for currently refractory osteopenic
disorders.

## Key facts

- **NIH application ID:** 3158026
- **Project number:** 5R01AR037308-06
- **Recipient organization:** DUKE UNIVERSITY
- **SAM.gov UEI:** TP7EK8DZV6N5
- **Principal Investigator:** L DARRYL QUARLES
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $253,118
- **Award type:** 5
- **Project period:** 1986-08-01 → 1995-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158026

## Citation

> US National Institutes of Health, RePORTER application 3158026, PHARMACOLOGICALLY INDUCED NEO-OSTEOGENESIS (5R01AR037308-06). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3158026. Licensed CC0.

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