# DPA BONE MINERAL AND STRENGTH OF LUMBAR VERTEBRA

> **NIH NIH R01** · MEDICAL COLLEGE OF WISCONSIN · 1987 · $76,071

## Abstract

Osteoporosis is a considerable health problem which affects many of the
nation's elderly and contributes significantly to the national health
cost.  The significance of theis work is in determining the relationship
between the strength of the vertebra, its bone mineral mass and areal
density measured using dual photon absorptiometric techniques.  Excised
vertebra will be mechanically loaded to failure to determine the
compressive strength of the anterior portion of the vertebra.  The bone
mineral mass and areal density will be measured using the conventional DPA
scanning technique and a new technique which employs a conventional gamma
camera and computer for the detector and analysis system.  The gamma camera
significantly improves resolution and data collection efficiency compared
to the current DPA technique, and measurements are now possible in the
lateral spine.  Measurement of the lateral spine is advantageous in that it
provides a direct measurement of the load bearing anterior portion of the
vertebra.  The objective of this study is to determine whether a
measurement of areal density restricted to the vertebral body is superior
for estimating the strength than the integrated measurement obtained in the
frontal projection in current DPA systems.  Successful validation of the
gamma camera and computer as a superior system for meaningful measurement
in the osteoporotic patient will allow accurate and sensitive bone
densitometry to be performed in a broad base of existing clinical
installations.

## Key facts

- **NIH application ID:** 3158190
- **Project number:** 5R01AR037530-02
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **SAM.gov UEI:** E8VWJXMMUQ67
- **Principal Investigator:** CHARLES R WILSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $76,071
- **Award type:** 5
- **Project period:** 1986-08-01 → 1988-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158190

## Citation

> US National Institutes of Health, RePORTER application 3158190, DPA BONE MINERAL AND STRENGTH OF LUMBAR VERTEBRA (5R01AR037530-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158190. Licensed CC0.

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