# CONTROLLED CARTILAGE REPAIR

> **NIH NIH R01** · CASE WESTERN RESERVE UNIVERSITY · 1989 · $247,169

## Abstract

We propose to study the repair of articular cartilage defects which have
been filled with committed chondrocytes or mesenchymal stem cells.
Committed chondrocytes will be isolated, expanded in supportive tissue
culture environments, and implanted with satisfactory delivery vehicles in
vivo repair sites. Mesenchymal stem cells will be identified, isolated, and
expanded. Techniques will be developed to isolate mesenchymal stem cells
from the bone marrow and periosteum of adult donors and to drive these
cells towards chondrocytic phenotype. Specific delivery vehicles will be
developed to immobilize cells in specific in vivo sites. Cell surface
markers will be utilized to identify these cells and to follow their
phenotypic differentiation and reparative integration into cartilage. The
regeneration of articular cartilage will be evaluated by quantitative
histology, immunohistochemistry, biomechanical and biochemistry parameters.
The immunogeneicity of the implants will be evaluated by a mixed implant
cell-leukocyte culture. The local host response will be measured by testing
synovial fluid for implant-specific antibody in a microcytotoxicity test.
The long-term goal of this proposal is to develop practical clinical
methodologies which utilize autologous cell-based technologies in the
regeneration of cartilagenous defects.

## Key facts

- **NIH application ID:** 3158306
- **Project number:** 2R01AR037726-04
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **SAM.gov UEI:** HJMKEF7EJW69
- **Principal Investigator:** VICTOR M GOLDBERG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $247,169
- **Award type:** 2
- **Project period:** 1986-08-01 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158306

## Citation

> US National Institutes of Health, RePORTER application 3158306, CONTROLLED CARTILAGE REPAIR (2R01AR037726-04). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3158306. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*