# T CELL ABNORMALITIES IN AUTOIMMUNE MRL/1PR

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 1989 · $113,386

## Abstract

Murine SLE is an appropriate model for human SLE, since most, if
not all of the immunological abnormalities fundamental to human
SLE can also be readily observe in the murine system.  The
MHL1pr/1pr mouse is one of the strains that spontaneously
develop SLE.  In addition, all 1pr/1pr mice develop massive
generalized lymph node enlargements as the disease progresses.
In these enlarged lymph nodes, more than 90% of the cells are T
cells.  This project is concerned mainly with the in vitro
physiology and immunobiology of the abnormal T cells in 1pr/1pr
mice, and the relationship between in vitro T cell abnormalities
and development of autoimmunity in vivo.  Our research goals are
summarized as follows:

1). Characterization of responsiveness of each individual T cell
subpopulation in 1pr/1pr mice to receptor driven activation
signals or polyclonal activators.
2). Characterization of the consequence of activation in vitro
with respect to cell surface phenotypes and their
differentiation state.  Correlation between in vitro
observations and in vivo pathogenesis.
3) Characterization of immune abnormalities in vitro and the
establishment of an in vitro model system for the study of
differentiation of 1pr/1pr T cells.

## Key facts

- **NIH application ID:** 3158378
- **Project number:** 5R01AR038018-04
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **SAM.gov UEI:** FLJ7DQKLL226
- **Principal Investigator:** MAN-SUN M SY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $113,386
- **Award type:** 5
- **Project period:** 1988-10-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158378

## Citation

> US National Institutes of Health, RePORTER application 3158378, T CELL ABNORMALITIES IN AUTOIMMUNE MRL/1PR (5R01AR038018-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158378. Licensed CC0.

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