# IMMUNOLOGIC PROPERTIES OF COLLAGEN

> **NIH NIH R01** · BETH ISRAEL DEACONESS MEDICAL CENTER · 1987 · $152,325

## Abstract

This project proposes to continue efforts to investigate the role of
autoimmune responses to collagen in the pathogensis of connective tissue
diseases.  The rationale for this project is based on the increasing
evidence that the articular manifestations of rheumatoid arthritis are, in
part, attributable to T cell mediated processes.  To elucidate more
precisely the cellular immune mechanisms contributing to the induction of
arthritis in rats or mice immunized with type II collagen, studies are
planned to partially purify a lymphokine induced by type II collagen which
is arthritogenic in rats and mice - arthritogenic factor.  Other studies
will attempt to analyze the T-cell repertoire to type II collagen in rats
by cloning techniques.  Additional experiments will further assess the
possible involvement of hypersensitivity to type II collagen in the
pathogenesis of adjuvant arthritis by ascertaining the cellular origin and
biochemical and functional nature of the collagen induced arthritogenic
factor activity present in this model.  By identifying antigen-specific
cellular effector mechanisms in animal models of inflammatory arthritis,
these studies have the potential to elucidate pathways that may operate and
be susceptible to modification in human disease.

## Key facts

- **NIH application ID:** 3158493
- **Project number:** 5R01AR038331-03
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **SAM.gov UEI:** C1CPANL3EWK4
- **Principal Investigator:** DAVID E TRENTHAM
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $152,325
- **Award type:** 5
- **Project period:** 1986-05-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158493

## Citation

> US National Institutes of Health, RePORTER application 3158493, IMMUNOLOGIC PROPERTIES OF COLLAGEN (5R01AR038331-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158493. Licensed CC0.

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