# HUMAN HETEROTOPIC BONE FACTOR

> **NIH NIH R01** · UNIVERSITY OF ROCHESTER · 1989 · $141,730

## Abstract

This proposal is aimed at isolating and purifying a molecule
obtained from human heterotopic bone.  This molecule stimulates
many of the cell parameters associated with bone formation.  In
the Specific Aims of this grant we propose to examine the
phenotypic changes which occur in bone and cartilage cells after
exposure to the molecule and to characterize the interactions of
other one target hormones with the factor.  We will also
determine if the stimulatory molecule obtained from a
pathological tissue if the same as the molecule obtained from
normal tissue.

## Key facts

- **NIH application ID:** 3158662
- **Project number:** 5R01AR038618-02
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **SAM.gov UEI:** F27KDXZMF9Y8
- **Principal Investigator:** J. Edward PUZAS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $141,730
- **Award type:** 5
- **Project period:** 1988-02-01 → 1991-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158662

## Citation

> US National Institutes of Health, RePORTER application 3158662, HUMAN HETEROTOPIC BONE FACTOR (5R01AR038618-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158662. Licensed CC0.

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