# HYBRIDOMA-PRODUCED AUTOANTIBODIES -- SYSTEMIC LUPUS

> **NIH NIH R01** · TUFTS MEDICAL CENTER · 1987 · $216,531

## Abstract

Hybridoma-produced autoantibodies to DNA will be used to analyze genetic and
cellular aspects of experimental systemic lupus erythematosus.  These monoclonal
autoantibodies, together with corresponding anti-idiotypic antibodies will be
employed to quantitate cross reactive idiotypes in serum as well as suppressor T
cells, helper T cells and B cells with specificity for autoantibodies to DNA.
Experiments will be done in MRL/I mice, which develop a severe and rapidly fatal
form of systemic lupus erythematosus.  The hybridoma autoantibodies will also be
used to study recognition of helical nucleic acids by proteins.

## Key facts

- **NIH application ID:** 3158808
- **Project number:** 5R01AR038820-02
- **Recipient organization:** TUFTS MEDICAL CENTER
- **SAM.gov UEI:** MY2ERHGDV956
- **Principal Investigator:** ROBERT S SCHWARTZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $216,531
- **Award type:** 5
- **Project period:** 1986-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158808

## Citation

> US National Institutes of Health, RePORTER application 3158808, HYBRIDOMA-PRODUCED AUTOANTIBODIES -- SYSTEMIC LUPUS (5R01AR038820-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158808. Licensed CC0.

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