# ORGANIZATION OF AUTOANTIBODY VH GENES

> **NIH NIH R01** · TUFTS MEDICAL CENTER · 1991 · $61,491

## Abstract

The goal of this project is to further understand the autoimmune
disease, systemic lupus erythematosis.  Cloned V genes from
autoantibodies will be used to investigate the origin and nature of
autoantibodies and the mechanism of autoantibody production as
compared to "normal" antibodies.  The hypothesis that
autoantibodies are encoded by a biased part of the normal
repertoire will be tested as will the role of somatic mutation and
idiotype networks.  The information gained from these
experiments may provide useful diagnostic and therapeutic
reagents for lupus.

## Key facts

- **NIH application ID:** 3158816
- **Project number:** 5R01AR038821-06
- **Recipient organization:** TUFTS MEDICAL CENTER
- **SAM.gov UEI:** MY2ERHGDV956
- **Principal Investigator:** KATHLEEN J BARRETT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $61,491
- **Award type:** 5
- **Project period:** 1986-09-01 → 1992-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158816

## Citation

> US National Institutes of Health, RePORTER application 3158816, ORGANIZATION OF AUTOANTIBODY VH GENES (5R01AR038821-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158816. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*