# LOCAL ANTIBIOTIC THERAPY OF OSTEOMYELITIS

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 1989 · $46,256

## Abstract

Chronic osteomyelitis is a difficult therapeutic problem,
frequently resulting in long term disability.  There are many
facets of chronic osteomyelitis (eg. regional hypovascularity, soft
tissue coverage, necrotic tissue and specific pathogenic
organisms) all of which must be addressed if eradication of
infection is to be achieved.  As part of the therapy for
osteomyelitis we have recently used local antibiotic
administration via an implantable pump.  An infusion pump is
implanted subcutaneously in the ipsilateral lower quadrant of the
abdomen.  The outflow catheters of the pump are brought
subcutaneously to the infected area and inserted in the
osteomyelitic defect.  The pump is filled at weekly intervals as an
outpatient.  We propose comparing this method of local
administration of antibiotics with systemic intravenous
administration in the treatment of chronic osteomyelitis.  In
addition to antibiotic therapy all patients will require surgical
management, eg: debridement; soft tissue coverage; and
stabilization of nonunions.  The project director will perform all
surgical procedures on patients included in the study.  Only
patients with a similar degree of severity of osteomyelitis, based
on a classification scheme proposed by Cierny (1), of the femur or
tibia will be included in the study to ensure a controlled
treatment group.  Efficacy of therapy will be evaluated according
to the following parameters:  (1)  local and systemic levels of
antibiotic; (2) incidence of side effects; (3) duration of
hospitalization; (4) cost of therapy; and, (5) incidence of
suppression or eradication of infection.

## Key facts

- **NIH application ID:** 3158918
- **Project number:** 5R01AR038901-03
- **Recipient organization:** WASHINGTON UNIVERSITY
- **SAM.gov UEI:** L6NFUM28LQM5
- **Principal Investigator:** CLAYTON PERRY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $46,256
- **Award type:** 5
- **Project period:** 1987-08-01 → 1991-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3158918

## Citation

> US National Institutes of Health, RePORTER application 3158918, LOCAL ANTIBIOTIC THERAPY OF OSTEOMYELITIS (5R01AR038901-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3158918. Licensed CC0.

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