# BONE PROTEINS--CHEMISTRY, SYNTHESIS, TISSUE LOCALIZATION

> **NIH NIH R01** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1992 · $165,579

## Abstract

The broad objectives of this research are to characterize rat bone non-
collagenous proteins that are made and secreted by osteoblasts and are
found in the calcified matrix of bone and to determine their functions.
The fundamental hypothesis on which these studies is based is that these
NCPs are involved in the formation of bone.  The recent demonstration that
two of the bone matrix proteins are cell attachment proteins while others
are growth factors indicate that some of the bone NPCs have activities
relating to cells.  The specific objectives of this research are: 1) to use
antibodies against bone matrix proteins as markers to study osteoblast
differentiation, 2) to determine the nature, location and biosynthesis of
the post-translational modifications of osteopontin, a phosphorylated cell
attachment protein, 3) to identify and characterize putative proteins
linking osteopontin to the organic matrix of bone (type I collagen) 4) to
continue studies on the characterization, biosynthesis and
immunolocalization of newly discovered bone matrix NCPs.  These studies
will advance our knowledge of the fundamental biochemical mechanisms
involved in osteogenesis.  This fundamental knowledge will be useful in
understanding the basic causes of certain genetic and systemic diseases
that affect bone.

## Key facts

- **NIH application ID:** 3159271
- **Project number:** 5R01AR039273-06
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **SAM.gov UEI:** ZUFBNVZ587D4
- **Principal Investigator:** WILLIAM T BUTLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $165,579
- **Award type:** 5
- **Project period:** 1987-06-01 → 1995-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159271

## Citation

> US National Institutes of Health, RePORTER application 3159271, BONE PROTEINS--CHEMISTRY, SYNTHESIS, TISSUE LOCALIZATION (5R01AR039273-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3159271. Licensed CC0.

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