# NMR STUDIES ON CONNECTIVE TISSUE PROTEOGLYCANS

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1989 · $114,709

## Abstract

Proteoglycans are macromolecules present in all connective
tissues.  The basic structural pattern of a proteoglycan molecule,
in which a core protein may be linked to several polysaccharide
chains, imparts a functional diversity which is further
accentuated by the difference in the structures of various
polysaccharide components.  Currently, our knowledge about the
role of the structure of the proteoglycans in relation to the
conformation, and the role of the conformation in relation to the
biological function, is somewhat rudimentary.  The current
investigation is aimed at filling some of the gaps in our knowledge
of the structure-conformation and conformation-function
relationships of the proteoglycans.  These investigations will be
carried out at the level of oligosaccharides and peptides.  Some of
these will be synthesized while others will be obtained from
naturally occurring proteoglycans by enzymatic and chemical
degradation.  The principal experimental technique that will be
employed is high-field NMR spectroscopy.  A wide variety of
NMR methods, conformational energy calculations and molecular
modelling studies will be employed during the course of this
investigation.

## Key facts

- **NIH application ID:** 3159324
- **Project number:** 5R01AR039301-02
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** NEPALLI RAMA KRISHNA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $114,709
- **Award type:** 5
- **Project period:** 1988-07-01 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159324

## Citation

> US National Institutes of Health, RePORTER application 3159324, NMR STUDIES ON CONNECTIVE TISSUE PROTEOGLYCANS (5R01AR039301-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3159324. Licensed CC0.

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