# SYSTEMIC IMPLICATIONS OF TOTAL JOINT REPLACEMENT

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 1991 · $175,317

## Abstract

Current clinical trends in total joint replacement (TJR) include
implantation in younger patients and the use of non-cemented,
porous coated metallic components which release greater amounts of
corrosion products.  In vitro and in vivo (animal and human)
studies suggest a wide range of possible local and systemic
biological sequelae to metallic release by TJRs.  The proposed
studies will address an important precursor to understanding the
clinical significance of such effects:  characterization of the
release transport an storage of metallic moieties in patients with
total hip replacements (THRs).  This proposal involves three
studies that will focus on distinct patient populations.  The first
study is a  prospective, longitudinal study of metal ion release
in patients undergoing primary THR with either a cementless
titanium-base alloy prosthesis, a cementless cobalt-base alloy
prosthesis or a cemented cobalt-base alloy prosthesis.  The second
study will examine metal ion release and local metal ion
accumulation in patients undergoing revision THR for aseptic
loosening of both cemented and cementless titanium-base alloy and
cobalt-base alloy prosthesis.  The third study will examine total
body metal inventories in deceased individuals with cemented and
cementless titanium-base alloy or cobalt-base alloy THRs.  The
primary analytical toll is Zeeman atomic absorption
spectrophotometry (ZAAS).

The results of theses studies will be critical in evaluating
prospective risk to patients of the use of emerging total joint
replacement technologies.

## Key facts

- **NIH application ID:** 3159341
- **Project number:** 5R01AR039310-03
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **SAM.gov UEI:** C155UU2TXCP3
- **Principal Investigator:** JORGE O GALANTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $175,317
- **Award type:** 5
- **Project period:** 1989-05-01 → 1993-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159341

## Citation

> US National Institutes of Health, RePORTER application 3159341, SYSTEMIC IMPLICATIONS OF TOTAL JOINT REPLACEMENT (5R01AR039310-03). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159341. Licensed CC0.

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