# BIOSYNTHETIC AND STRUCTURAL STUDIES ON MELANINS

> **NIH NIH R01** · ADVANCED POLYMER SYSTEMS · 1988 · $114,373

## Abstract

The objectives of this study are to:

1) develop analytical techniques to characterize and quantify
melanin polymers,

2)  develop standard protocols for a) isolation of natural melanins
and  b) in vitro preparation of melanin chromophores.

3) compare and contrast, the melanin polymers prepared in vitro
from tyrosinases isolated from various sources.

4) utilize biosynthetic methodology to examine the structures of
mammalian melanins, and

5)  elucidate the biosynthetic pathway between dopa and the
polymeric melanin chromophores

During the course of these studies carbon-13 and nitrogen-15
labeled melanins will be produced and characterized by NMR,
ESR, FTIR and ESCA analyses.

## Key facts

- **NIH application ID:** 3159473
- **Project number:** 7R01AR039420-02
- **Recipient organization:** ADVANCED POLYMER SYSTEMS
- **Principal Investigator:** MILES ROBERT CHEDEKEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $114,373
- **Award type:** 7
- **Project period:** 1988-05-16 → 1993-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159473

## Citation

> US National Institutes of Health, RePORTER application 3159473, BIOSYNTHETIC AND STRUCTURAL STUDIES ON MELANINS (7R01AR039420-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3159473. Licensed CC0.

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