# ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 1988 · $98,365

## Abstract

The primary goal of this investigation is to improve our
understanding of the functional role of the anterior cruciate
ligament from a biomechanical viewpoint.  We have hypothesized that
we will be able to identify substantial and reproducible adaptive
changes in loading movement patterns between normal individuals and
patients with no anterior cruciate ligament (ACL). Further, it is
hypothesized that the adaptation may occur over a period of time
following an anterior cruciate ligament rupture and may affect
clinical changes.

Quantitative biomechanical information on the loading and movement
of the lower extremity, myoelectric activity and time-distance
information will be collected on normal subjects and patients with
arthroscopically documented isolated complete tears of the anterior
cruciate ligament.  The ACL- subjects will be tested three times
over a period of three years.  The initial test will be given
between six months and one year after the initial injury.
Preliminary work suggests that the adaptive changes in ACL-
individuals is substantial and reproducible.

Information generated from this study will provide a first step in
increasing our understanding of the functional adaptation
associated with a missing anterior cruciate ligament.  This
information, combined with a wealth of available in vitro
laboratory studies as well as mathematical models, will be
extremely valuable in defining the functional role of the ACL as
well as providing needed input into the clinical management of the
patient with an injured anterior cruciate ligament.

## Key facts

- **NIH application ID:** 3159476
- **Project number:** 1R01AR039421-01
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **SAM.gov UEI:** C155UU2TXCP3
- **Principal Investigator:** THOMAS P ANDRIACCHI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $98,365
- **Award type:** 1
- **Project period:** 1988-04-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159476

## Citation

> US National Institutes of Health, RePORTER application 3159476, ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS (1R01AR039421-01). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159476. Licensed CC0.

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