# REGULATION OF INFLAMMATION IN EXPERIMENTAL ARTHRITIS

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 1992 · $182,170

## Abstract

The broad objective of these investigations is to establish the
molecular, cellular and genetic basis of the acute and chronic
granulomatous inflammation induced by the peptidoglycan-polysaccharide
polymers isolated from group A streptococcal cell walls (PG-APS).  These
well-characterized PG-APS polymers are resistant to biodegradation,
immunogenic and capable of modulating the immune response.  Injection of
a susceptible strain of rat with a PG-APS polymer of appropriate size and
structure will induce a prolonged, remittent, chronic erosive arthritis
which resembles many features of human inflammatory arthritis.  This
experimental model provides a defined structure upon which to focus study
of the etiology of human rheumatoid and reactive arthritides, and an
opportunity to examine in vivo the function of a variety of inflammatory
mediator in evolving inflammation of joints.  The first specific aim is
designed to test the capacity of several highly purified cytokine or
eicosanoid mediators to cause reactivation of erosive synovitis which has
been initiated by PG-APS.  Another experimental approach will involve
testing the effect of specific inhibitors of cytokines or arachidonic
acid metabolites on recurrence of arthritis induced by PG=APS or
lipopolysaccharide.  The effect of long term administration of
nonsteroidal anti-inflammatory agents and steroids on progression of
experimental chronic remittent erosive arthritis induced by PG-APS will
also be examined.  Another specific aim is to characterize an interleukin
1 inhibitor produced by rat macrophages stimulated by PG-APS and to
determine its role in regulation of joint inflammation induced by PG-APS.

## Key facts

- **NIH application ID:** 3159536
- **Project number:** 5R01AR039480-04
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **SAM.gov UEI:** D3LHU66KBLD5
- **Principal Investigator:** JOHN H SCHWAB
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $182,170
- **Award type:** 5
- **Project period:** 1989-04-30 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159536

## Citation

> US National Institutes of Health, RePORTER application 3159536, REGULATION OF INFLAMMATION IN EXPERIMENTAL ARTHRITIS (5R01AR039480-04). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159536. Licensed CC0.

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