# BIOCHEMICAL AND CELLULAR RESPONSES TO BIOMATERIALS

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 1989 · $134,623

## Abstract

Procedures for total joint replacement have revolutionized the
treatment of patients with end-stage destructive arthritis.
Although improvements in biomaterials and surgical techniques
have yielded excellent clinical results, long-term followup studies
reveal an alarming rate of prosthetic loosening that ultimately
requires revision surgery.  Despite numerous studies describing
the tissue reaction associated with orthopedic implants, very
little is known regarding the specific cellular and biochemical
events that determine the characteristics of the histologic and
connective tissue response to these materials.  The goal of this
proposal is to develope an in vitro cell culture model employing
bone and other connective tissue cells to study the effects of
orthopaedic implant biomaterials on the expression of
differentiated cell function.  Biochemical and molecular
mechanisms regulating general cellular activities such as
attachment, proliferation, cytoskeletal organization and matrix
biosynthesis will be investigated and comparative results obtained
in different cell types will help establish the specificity of the
observations made with bone cells.  In addition this model will be
used to explore experimental approaches for modulating the
phenotypic expression of bone and other connective tissue cells
grown on implant materials.  A suitable in vitro model for
studying the specific biologic processes involved in the interaction
between orthopedic biomaterials and connective tissue cells
should be useful in developing improved techniques and
biomaterials for total joint replacement.

## Key facts

- **NIH application ID:** 3159599
- **Project number:** 5R01AR039515-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **SAM.gov UEI:** FLJ7DQKLL226
- **Principal Investigator:** STEVEN GOLDRING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $134,623
- **Award type:** 5
- **Project period:** 1988-07-01 → 1993-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159599

## Citation

> US National Institutes of Health, RePORTER application 3159599, BIOCHEMICAL AND CELLULAR RESPONSES TO BIOMATERIALS (5R01AR039515-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3159599. Licensed CC0.

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