# EXERCISE & BONE MASS IN YOUNG  WOMEN

> **NIH NIH R01** · PURDUE UNIVERSITY · 1993 · $279,793

## Abstract

DESCRIPTION:  (Adapted from the applicant's abstract):  The effect of
weightbearing exercise on bone mass, bone turnover, and calcium absorption
will be assessed over 2 years in women aged 18-30 years.  A feature of the
proposed study which distinguishes it from others is that the women will be
premenopausal.  This population, as opposed to a population of
postmenopausal women in whom bone loss is already established was selected
because it is proposed that an increase in activity in young women is more
effective in reducing the risk of osteoporosis.  Subjects will be randomly
assigned to the exercise program which consists of aerobic, weightbearing
exercise.  Fitness will be measured by maximal and submaximal oxygen uptake
on a treadmill and body composition by underwater weighing and
bioelectrical impedance analysis.  Bone mass will be evaluated by single
and dual photon absorptiometry of the radius, hip, and spine.  Bone
turnover will be assessed by plasma bone-Gla-protein, bone resorption by
fasting urinary excretion of hydroxyproline, and bone formation by serum
alkaline phosphatase.  If the exercise program does increase bone mass or
turnover, it is likely to increase calcium absorption.  Calcium absorption
will be determined using a stable (nonradioactive) isotope of calcium.  A
positive effect of exercise on bone mass in young women may have important
implications in the prevention of osteoporosis later in life.

## Key facts

- **NIH application ID:** 3159679
- **Project number:** 5R01AR039560-03
- **Recipient organization:** PURDUE UNIVERSITY
- **SAM.gov UEI:** YRXVL4JYCEF5
- **Principal Investigator:** Connie Marie Weaver
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $279,793
- **Award type:** 5
- **Project period:** 1991-02-10 → 1995-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159679

## Citation

> US National Institutes of Health, RePORTER application 3159679, EXERCISE & BONE MASS IN YOUNG  WOMEN (5R01AR039560-03). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159679. Licensed CC0.

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