# CUTANEOUS AND ARTICULAR MANIFESTATIONS IN HIV DISEASES

> **NIH NIH R01** · HOSPITAL FOR JOINT DISEASES ORTHO INST · 1988 · $396,932

## Abstract

A group of diseases including psoriasis, arthritis and Reiters
syndrome, and designated for convenience PARS, has been found to
occur in association with each other and at elevated frequency in
HIV infected individuals.  This is a proposal to gather information
relevant to their occurrence and natural history, but most
importantly to initiate a deeper inquiry into the immunologic
mechanisms of disease and the genetic factors encoded by the MHC
that may influence their susceptibility.  An underlying hypothesis
has been proposed, occasioned by the occurrence of the PARS
diseases in setting of helper T cell deficiency, namely that they
are diseases of immune recognition in which T cells of the CD8
cytotoxic suppressor sublineage recognize determinants on or
presented by MHC class I molecule alleles involved in determining
disease susceptibility.  Much of the proposed is research directed
to gaining insight into mechanisms and phenomena relevant to this
hypothesis.  The association of PARS diseases with HIV infection
also offers the opportunity to examine aspects of disease
classification.  The occurrence of Reiter's syndrome and psoriatic
arthritis and the absence of ankylosing spondylitis in AIDS
suggests different mechanisms and susceptibility factors in these
diseases.  It is anticipated that insights into psoriasis and the
spondyloarthropathies acquired in this proposal will be applicable
to these diseases as they occur in the general population.

## Key facts

- **NIH application ID:** 3159811
- **Project number:** 1R01AR039626-01
- **Recipient organization:** HOSPITAL FOR JOINT DISEASES ORTHO INST
- **Principal Investigator:** Robert J Winchester
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $396,932
- **Award type:** 1
- **Project period:** 1988-09-30 → 1993-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159811

## Citation

> US National Institutes of Health, RePORTER application 3159811, CUTANEOUS AND ARTICULAR MANIFESTATIONS IN HIV DISEASES (1R01AR039626-01). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159811. Licensed CC0.

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