# BIOCHEMICAL MARKERS AND BONE LOSS IN OLDER WOMEN

> **NIH NIH R01** · HENRY FORD HEALTH SYSTEM · 1993 · $91,852

## Abstract

This study proposes to prospectively monitor bone mass over a two
year period in healthy women who are 10 or more years post-
menopausal, and to relate the rate of bone loss to biochemical
markers of bone remodelling measured at entry into the study.  In
a subset of the study population histologic assessment of bone
remodelling will also be done at entry and related to the
prospectively determined rate of bone loss.  The methods of bone
mass measurement (single and dual photon absorptiometry,
quantitative densitometric radiography and quantitative computed
tomography) permits evaluation of cortical and cancellous bone at
different skeletal sites where osteoporotic fractures are common.
The biochemical markers of bone remodelling include bone specific
alkaline phosphatase, tartrate-resistant acid phosphatase and
osteocalcin in the blood and urinary excretion of calcium and
hydroxyproline.  Additionally, in the subset having the bone
biopsy, the short term response of these markers to calcitonin will
be measured in an"effort to improve sensitivity and specificity.
The principal objective of this study is to determine whether, in
this age group, the rate of bone loss can be predicted when the
patient first presents for evaluation.  If such a prediction is
possible it would form a rational basis for subsequent management
decisions aimed at minimizing the risk of sustaining
osteoporotic fractures later in life.  These decisions would be
made not only on the prevailing bone mass but on the predicted
change in bone mass with time.  This study could serve as a guide
to the design of future clinical trials in this field.

## Key facts

- **NIH application ID:** 3159863
- **Project number:** 5R01AR039657-05
- **Recipient organization:** HENRY FORD HEALTH SYSTEM
- **SAM.gov UEI:** R9NXPE2GTCN9
- **Principal Investigator:** Michael KLEEREKOPER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $91,852
- **Award type:** 5
- **Project period:** 1989-05-01 → 1993-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159863

## Citation

> US National Institutes of Health, RePORTER application 3159863, BIOCHEMICAL MARKERS AND BONE LOSS IN OLDER WOMEN (5R01AR039657-05). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159863. Licensed CC0.

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