# MECHANISMS OF PARENTERAL NUTRITION ASSOCIATED BONE LOSS

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1991 · $166,528

## Abstract

Previous research from this laboratory would suggest that immobilization
induced by acute illness and bypassing the oral route of alimentation may
account for the depressed bone formation and increased bone resorption
observed in some patients dependent on parental nutrition.  Because of the
heterogeneity of human subjects underlying diseases, it is proposed to
utilize a non-human primate model to study the interrelationship between
the mode of nutrition support, immobilization, and bone formation and
resorption.  To test these interrelationships bone formation rates will be
determined in animals fed orally versus animals fed intravenously and
between those freely mobile versus those constrained by a jacket and
tether system; serum from those animals will be tested for levels of
essential bone hormones including parathyroid hormone and insulin-like
growth factor 1; serum from test animals will be tested in vitro for its
effect on bone formation and resorption; and osteoblast cells from test
animals will be tested directly for proliferation and differentiation.
The goal is to better understand one of the more prevalent complications
observed in patients dependent on long term intravenous nutrition support,
and to enhance our understanding of metabolic bone disease in general.

## Key facts

- **NIH application ID:** 3159886
- **Project number:** 5R01AR039688-02
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** EDWARD W LIPKIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $166,528
- **Award type:** 5
- **Project period:** 1990-07-01 → 1994-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159886

## Citation

> US National Institutes of Health, RePORTER application 3159886, MECHANISMS OF PARENTERAL NUTRITION ASSOCIATED BONE LOSS (5R01AR039688-02). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3159886. Licensed CC0.

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