# RESPIRATORY MUSCLE ENERGETICS DURING EXERCISE

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 1991 · $147,546

## Abstract

Recent reports of inspiratory muscle fatigue in athletes following both
high-intensity short-term as well as prolonged endurance exercise have
focussed our attention on the question "whether the metabolic O2
requirements of the respiratory muscles are sufficient to limit VO2max and
exercise capacity of the locomotor muscles?"  As yet only limited
fragmented information is available to even begin to answer this very
important question.  Therefore, we are proposing experiments in healthy
miniature swine where blood flow, capillary density, and aerobic metabolic
capacity of all respiratory muscles as well as phrenic extraction of O2,
lactate and blood-borne substrates, and possible phrenic ammonia production
will be studied at rest, and during sub-maximal and maximal exercise
performed in normoxia, hypoxia, and hyperoxia without as well as with
inspiratory resistive breathing.  In the first year the experimentation
will be on "sedentary" animals, and these data will serve as control for
the second year experiments to be carried out on "exercise-trained"
animals.  Techniques to be employed in these studies are considered
standard, routine, and are widely used; and we also have extensive
experience with these procedures.  It is believed that proposed research
will significantly enhance our knowledge of energetics of respiratory
muscles during rest and exercise, and this knowledge may also help improve
management of situations where respiratory muscle function may be
compromised.

## Key facts

- **NIH application ID:** 3159999
- **Project number:** 1R01AR039787-01A2
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **SAM.gov UEI:** Y8CWNJRCNN91
- **Principal Investigator:** MURLI MANOHAR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $147,546
- **Award type:** 1
- **Project period:** 1991-09-20 → 1993-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3159999

## Citation

> US National Institutes of Health, RePORTER application 3159999, RESPIRATORY MUSCLE ENERGETICS DURING EXERCISE (1R01AR039787-01A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3159999. Licensed CC0.

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