# INCIDENCE, QUANTITATION OF A TUMOR PROTEIN (ONCOMODULIN)

> **NIH NIH R01** · NATIONAL RESEARCH COUNCIL OF CANADA · 1987 · $76,999

## Abstract

Neoplastic transformation changes the basal concentration of several
calcium-binding proteins, calmodulin, S-100, and skin CaBP.  The
oncodevelopmental calcium-binding protein oncomodulin may also appear in
neoplasia, but is different from these others in that it is not found in
normal rodent or human adult tissue, and appears in 85% of tumours of
diverse origin.  It is the long term objective to fit the appearance of
oncomodulin into this general perturbation in calcium transport and
modulator proteins which must be responsible for some part of the
neoplastic phenotype.  We must determine whether the expression of the
oncomodulin gene is related to the functioning of a particular oncogene, or
insertion of a virally borne oncongene into a specific part of the cell
genome, or is a general response to neoplastic development.  Also of
interest is whether transfection of normal cells by DNA from chemically
transformed cells activates the oncomodulin gene while inducing neoplastic
transformation.  This will be achieved by both quantitative and qualitative
oncomodulin screening of many different cell types infected by competent,
transformation-defective, and temperature sensitive oncogenic viral
mutants, or transformed by different chemical carcinogens.  The cellular
function of oncomodulin will be sought by establishing first the ultra-
structural subcellular location of this protein, and by determining whether
oncomodulin is responsible for tumour properties, such as invasiveness, by
using as a model the normally invasive trophoblast cell, which is one of
the few non-neoplastic cells that make this protein.

## Key facts

- **NIH application ID:** 3170016
- **Project number:** 5R01CA031898-06
- **Recipient organization:** NATIONAL RESEARCH COUNCIL OF CANADA
- **Principal Investigator:** JOHN P MACMANUS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $76,999
- **Award type:** 5
- **Project period:** 1982-06-01 → 1988-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170016

## Citation

> US National Institutes of Health, RePORTER application 3170016, INCIDENCE, QUANTITATION OF A TUMOR PROTEIN (ONCOMODULIN) (5R01CA031898-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170016. Licensed CC0.

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