# ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTION

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1989 · $248,979

## Abstract

This prospective cohort study of the residents of Leisure World
Laguna Hills, a retirement community near Los Angeles, is being
conducted to evaluate the effects of health-related and life-style
practices on disease etiology and prevention in older adults.  With
this proposal 10 years of follow-up on the cohort members will be
completed to provide sufficient numbers of incident cases of
several chronic diseases to meet the specific aims of:  (1)
Evaluating the risks and benefits of estrogen replacement therapy
in terms of incident disease and mortality (including endometrial
cancer, breast cancer, osteoporotic fractures, acute myocardial
infarction, and stroke, plus lymphoma and leukemia, ovarian cancer,
rheumatoid arthritis, cholelithiasis, and phlebitis).  (2)
Investigating the effects of dietary factors, elective drugs,
smoking, coffee and alcohol consumption on risk of cancer
(including bladder, breast, and colon cancers).  (3) Analyzing the
associations of cardiovascular and cerebrovascular diseases and
exercise, alcohol intake, and aspirin.  (4) Assessing the effects
of life-style practices on other chronic diseases (including
gastrointestinal hemorrhage and ulcers, renal failure, benign
prostatic hypertrophy, benign breast disease, inflammatory bowel
disease, senile cataracts, and glaucoma).  The cohort members,
initially enrolled in 1981, number 13987.  All members of the
cohort will be followed to death or to March 31, 1992.  Baseline
data from the original questionnaire and updated information from
two follow-up questionnaires have already been obtained.  The
original questionnaire covered basic demographic information,
medical history, personal habits, medical screening, vitamin
supplement and dietary intake, and (for women) menstrual and
reproductive histories.  The two follow-up questionnaires asked
current intake of vitamin supplements and hormone replacement
therapy, recent hospitalizations, and included short dietary
sections.  Acquisition of all hospital discharge diagnoses for
Leisure World residents from three local hospitals and pathologic
cancer diagnoses from five local hospitals and from the Cancer
Surveillance Programs of Los Angeles and Orange Counties is
ongoing.  Decedents are identified by reviewing all death
certificates of Orange County residents, by the community business
office, from the obituary columns of the local newspaper, from
information provided by relatives and friends, and by search of the
National Death Index.  One additional follow-up questionnaire will
be sent to all subjects not known to be deceased during the tenth
anniversary year of the study, 1991, to verify vital status.  The
primary method of analysis will be to fit Poisson regression models
to group data consisting of multidimensional classification of
disease cases and person-years of observation by discrete
categories of age, calendar period, and various aspects of
exposure.  Extension of these models for use with disease rates and
exposure v...

## Key facts

- **NIH application ID:** 3170179
- **Project number:** 2R01CA032197-08
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** ANNLIA PAGANINI- HILL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $248,979
- **Award type:** 2
- **Project period:** 1982-04-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170179

## Citation

> US National Institutes of Health, RePORTER application 3170179, ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTION (2R01CA032197-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170179. Licensed CC0.

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