# ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTION

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1988 · $158,260

## Abstract

This cohort study is designed to measure the risks and benefits of
menopausal estrogen replacement therapy (ERT) in terms of incidence disease
and mortality (of endometrial cancer, breast cancer, hip fracture, and
acute myocardial infarction); to study the effect of dietary and
supplemental intake of vitamin A on the development of epithelial cancer,
especially lung cancer, especially lung cancer; and to evaluate the risks
and benefits associated with other health-related practices in older adults.

Detailed health surveys have been collected on 12,410 residents of Leisure
World Laguna Hills (Cohorts I,II,III) and those from recent move-ins
(Cohort IV) are now being obtained.  The questionnaire covers basic
demographic information, medical history, personal habits, medical
screening, vitamin usage, and (for women) menstrual and reproductive
histories including use of hormone replacement therapy.

Followup questionnaires were sent to all living members of Cohorts I and II
in 1983 and to those of Cohorts I, II and III in 1985.  Non-respondents to
this most recent mailing are being telephoned to encourage continued
participation in this study and those lost to followup traced for a current
address.  Additional followups will be conducted utilizing the same
procedures in January 1988 and September 1990.

Abstraction, coding and data entry of hospital discharge diagnoses (from
three local hospitals), cancer pathology reports (from five local
hospitals), and death certificates are ongoing and will continue throughout
the funding period.

The data from this cohort study will be regularly analyzed and prepared for
publication.  In particular, we will evaluate the modifications in risks of
individual disease (endometrial and breast cancers, osteoporotic fractures,
coronary heart disease, gallbladder disease) associated with different
doses, durations, and timing of ERT, and the potential confounding and
modifying effects of other factors such as weight, previous disease, and
age at and type of menopause.  In addition, the relationship between
certain life-style practices (such as exercise, weight, analgesic use,
alcohol consumption, smoking, vitamin supplementation, and the intake of
certain food items) and certain chronic diseases will be assessed.

## Key facts

- **NIH application ID:** 3170183
- **Project number:** 5R01CA032197-07
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** ANNLIA PAGANINI- HILL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $158,260
- **Award type:** 5
- **Project period:** 1982-04-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170183

## Citation

> US National Institutes of Health, RePORTER application 3170183, ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTION (5R01CA032197-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170183. Licensed CC0.

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