# LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 1988 · $231,187

## Abstract

This is a basic and clinical study to elucidate the mechanisms of action of
hematoporophyrin derivative plus light in the treatment and diagnosis of
cancer.  Three basic cell areas of investigation are proposed;

1. Further clarifying the cellular sites of binding;

2. Identifying the sites of phototoxicity (just because HpD binds to a
particular site does not mean that that is the site of phototoxicity);

3. Identifying which HpD subcomponents are phototoxic and which are
fluorescent (some may be both).

In vitro studies will employ malignant and non-malignant cell lines with
particular emphasis on toxicity and sites of binding structural
alterations.  Techniques used will be fluorescence detection, electron
microscopy, and tissue culture.  Animal studies will involve the use of
different tumor systems with the main objectives being pathological and
fluorescence analysis of HpD and light effects.  Diagnostic studies will be
done on human patients employing fluorescence detection in vivo plus serial
biopsies followed by fluorescence analysis.  Human treatment will involve
treating patients with head and neck, gynecological, and bladder cancer.

## Key facts

- **NIH application ID:** 3170229
- **Project number:** 5R01CA032248-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **SAM.gov UEI:** MJC5FCYQTPE6
- **Principal Investigator:** Michael W. Berns
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $231,187
- **Award type:** 5
- **Project period:** 1982-05-01 → 1988-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170229

## Citation

> US National Institutes of Health, RePORTER application 3170229, LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS (5R01CA032248-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170229. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*