# LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 1991 · $307,272

## Abstract

This is a five year proposal to continue studies on the
mechanism(s) and efficacy (human) of photodynamic therapy (PDT) of
cancer.  This is a combined basic and applied approach involving
basic scientists and clinicians.  Studies are proposed at three
levels:  (1) subcellular/cellular, (2) tissue/animal, (3) human
clinical.  HpD (DHE/Photorin II) will be investigated and compared
to new photosensitizers that will be synthesized by a collaborating
chemist.

The subcellular and cellular studies will involve studies on (a)
subcellular binding, (b) kinetics of sensitizer uptake and
excretion, (c) cellular phototoxicity, (d) detection and
measurement of singlet oxygen.  The tissue and animal model studies
will involve (a) examination of three rodent animal models (EMT-6,
RIF, and rat colon adenocarcinoma), (b) a vascular chicken comb
model, (c) and angiogenic-induce ocular vascular model.  The
mechanism of PDT will be examined using techniques of histology,
electron microscopy, spectroscopy, and cell culture.  The human
clinical studies will involve correlation of tumor fluorescence
with therapeutic response in recurrent breast cancer, and the
development of a topical application of photosensitizer for the
treatment of early stage neoplasia in the gynecological tract.

## Key facts

- **NIH application ID:** 3170231
- **Project number:** 5R01CA032248-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **SAM.gov UEI:** MJC5FCYQTPE6
- **Principal Investigator:** Michael W. Berns
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $307,272
- **Award type:** 5
- **Project period:** 1982-05-01 → 1993-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170231

## Citation

> US National Institutes of Health, RePORTER application 3170231, LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS (5R01CA032248-09). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3170231. Licensed CC0.

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