# NICOTINE AND TAR INTAKE DURING CIGARETTE SMOKING

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1988 · $192,088

## Abstract

The objectives of this proposal are (1) to develop methods for quantitating
daily exposure to nicotine, tar and carbon monoxide while smoking
cigarettes or consuming smokeless tobacco; (2) to apply these methods to
study exposure to toxic substances while smoking different numbers or
different brands of cigarettes, and (3) to study other factors which are
known to influence the intake and effects of tar and nicotine.  Assays for
quantitating urinary and, if possible, blood concentrations of polycyclic
aromatic hydrocarbons, solanesol (a tobacco-specific terpene alcohol),
tobacco-specific nitroso compounds and various combustion gases will be
developed.  Consumption of nicotine will be measured using pharmacokinetic
data obtained after intravenous infusion of nicotine in combination with
nicotine blood concentration data obtained over 24 hours while smoking in
volunteer subjects on a clinical study center, or using casual blood level
of nicotine and cotinine in outpatient studies.  Using these methods, the
effects of smoking different numbers of cigarettes, different tobacco
products, i.e., pipes, cigars, snuff and chewing tobacco, and smoking
cigarettes with different yields will be studied.  In addition, the
influence of alcohol and caffeine on nicotine and tar intake, as well as on
the metabolism of nicotine and the cardiovascular effects of cigarette
smoking, will be studied.  Assays developed in our studies will be useful
in assessing exposure to toxic components of tobacco smoke in epidemiologic
studies and will provide specific information about potential health
hazards of different tobacco products.  The alcohol and caffeine studies
will further our understanding of the influence of these commonly used
drugs on smoking behavior and its consequences.  Our studies may lead to
more effective interventions to reduce the extent and harmful consequences
of cigarette smoking.

## Key facts

- **NIH application ID:** 3170344
- **Project number:** 5R01CA032389-07
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** NEAL L BENOWITZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $192,088
- **Award type:** 5
- **Project period:** 1982-07-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170344

## Citation

> US National Institutes of Health, RePORTER application 3170344, NICOTINE AND TAR INTAKE DURING CIGARETTE SMOKING (5R01CA032389-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170344. Licensed CC0.

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