# STUDIES ON TUMOR DORMANCY AND EMERGENCE

> **NIH NIH R01** · HAHNEMANN UNIVERSITY · 1987 · $181,929

## Abstract

In the tumor-dormant state intended for further study, small numbers of
lethal L5178Y lymphoma cells persist in the peritoneal cavity of clinically
normal DBA/2 mice for many weeks before growing out to produce an ascitic
tumor.  We have identified host cells involved in the establishment,
maintenance, and termination of the tumor-dormant state.  We intend here to
modulate the growth-restraint mechanisms that maintain the tumor cells in a
dormant state and to manipulate the dormant tumor cell population so as to
either prolong or terminate the tumor-dormant state. We will further
characterize the tumor cells isolated at various stages of tumor-dormant
state and evaluate the effects of pregnancy and stress on the tumor-dormant
state.  (MI)

## Key facts

- **NIH application ID:** 3170460
- **Project number:** 5R01CA032577-07
- **Recipient organization:** HAHNEMANN UNIVERSITY
- **Principal Investigator:** E. FREDERICK WHEELOCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $181,929
- **Award type:** 5
- **Project period:** 1981-09-30 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170460

## Citation

> US National Institutes of Health, RePORTER application 3170460, STUDIES ON TUMOR DORMANCY AND EMERGENCE (5R01CA032577-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170460. Licensed CC0.

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