# GROWTH FACTORS FOR RAT MAMMARY CANCER

> **NIH NIH R01** · MOUNT SINAI SCHOOL OF MEDICINE OF CUNY · 1987 · $141,012

## Abstract

Rat mammary tumor MTW9 can be grown in rats coimplanted with a
mammosomatotropic tumor MtTW10 which secretes a factor which prevents
ovariectomy-induced regression (OIR).  We called this factor galactomedin.
The factor is not prolactin, GH, ACTH or any other known steroid.  An assay
for this activity is possible based upon prevention of ovariectomy induced
regression in the hormonally responsive rat tumor-MTW9-D, by injection of
serum from MtTW10 bearing rat into ovariectomized-MTW9-rats.  Basic
extracts from MtTW10 tumor inhibit the growth of MTW9 cell cultures.  If
this inhibition represents the putative galactomedin the in vitro assay
will be used in an effort to isolate galactomedin; if the activity is not
identical, the in vivo activity, though expensive and slow, is adequate for
the isolation of galactomedin.

## Key facts

- **NIH application ID:** 3170481
- **Project number:** 5R01CA032581-04
- **Recipient organization:** MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
- **Principal Investigator:** VINCENT P. HOLLANDER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $141,012
- **Award type:** 5
- **Project period:** 1981-12-01 → 1987-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170481

## Citation

> US National Institutes of Health, RePORTER application 3170481, GROWTH FACTORS FOR RAT MAMMARY CANCER (5R01CA032581-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170481. Licensed CC0.

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