# ANTITUMOR AND ANTIVIRAL NUCLEOSIDE ANALOGUES

> **NIH NIH R01** · BARBARA ANN KARMANOS CANCER INSTITUTE · 1987 · $258,009

## Abstract

Novel nucleoside analogues will be prepared and studied as
potential antitumor and antiviral agents.  These compounds will
include:  (i) "Hydroxycarbocyclic" analogues of cytidine, 3-
deazaadenosine, vidarabine and cytarabine, (ii) unsaturated
carbocyclic nucleoside analogues related to neplanocin A
including L-homocysteinylneplanocin A, (iii) phosphonate
derivatives of open-chain unsaturated nucleoside analogues and
(iv) analogues of adenosine deaminase inhibitor EHNA.  All
compounds will be obtained by chemical synthesis.  Analogues (i)
and (ii) will be obtained either in racemic form or optically pure
by a new chemico-enzymatic approach.

Antitumor activity and mechanism of action of the active
analogues will be studied in vitro and in vivo in murine leukemia L
1210, P388, and sixteen solid tumor systems.  Particular attention
will be paid to:  (i) inhibition of macromolecular synthesis, (ii)
reversal studies with specific metabolites, (iii) alterations in
nucleotide pool sizes, and (iv) effects on RNA maturation.
Antiviral activity of the obtained analogues will also be
investigated.

Suitable analogues will be studied as substrates (inhibitors) of
adenosine deaminase and adenosine homocysteine hydrolase.

## Key facts

- **NIH application ID:** 3170631
- **Project number:** 2R01CA032779-04
- **Recipient organization:** BARBARA ANN KARMANOS CANCER INSTITUTE
- **SAM.gov UEI:** NAJZPZ4GN5B3
- **Principal Investigator:** JIRI ZEMLICKA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $258,009
- **Award type:** 2
- **Project period:** 1984-07-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170631

## Citation

> US National Institutes of Health, RePORTER application 3170631, ANTITUMOR AND ANTIVIRAL NUCLEOSIDE ANALOGUES (2R01CA032779-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170631. Licensed CC0.

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