# ANTITUMOR AND ANTIVIRAL NUCLEOSIDE ANALOGUES

> **NIH NIH R01** · BARBARA ANN KARMANOS CANCER INSTITUTE · 1993 · $242,897

## Abstract

DESCRIPTION:  ( Adapted from Applicant's Abstract).  New nucleoside
analogues will be prepared and studied as potential antiviral and antitumor
agents.  These compounds will include:  i) Enantiomers of active inhibitors
of HIV, adenallene and cytallene.  ii) Additional analogues of an allene
type including fluoro derivatives and allenediols, iii) spirocyclic
analogues of allenes, iv) acetylenic and olefinic acyclic nucleoside
analogues and their phosphonates, v) 2'-oxacarbocyclic analogues of
nucleosides ("isonucleosides") and vi) triphosphate derivatives of allenes
for studies of mechanisms of action of adenallene and cytallene.  Antitumor
activity and mechanism of action of the active analogues will be studied in
vitro and in vivo using murine leukemia L 1210 and a number of other tumor
systems including solid tumors.  Antiviral effects will be investigated in
several assays with DNA and RNA viruses with a particular emphasis on HIV.
The appropriate analogues (adenine derivatives) will be tested as
substrates for adenosine deaminase.

## Key facts

- **NIH application ID:** 3170638
- **Project number:** 5R01CA032779-09
- **Recipient organization:** BARBARA ANN KARMANOS CANCER INSTITUTE
- **SAM.gov UEI:** NAJZPZ4GN5B3
- **Principal Investigator:** JIRI ZEMLICKA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $242,897
- **Award type:** 5
- **Project period:** 1984-07-01 → 1995-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170638

## Citation

> US National Institutes of Health, RePORTER application 3170638, ANTITUMOR AND ANTIVIRAL NUCLEOSIDE ANALOGUES (5R01CA032779-09). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3170638. Licensed CC0.

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