# HYPERTHERMIA, RADIATION, MEMBRANE STRUCTURE AND FUNCTION

> **NIH NIH R01** · STANFORD UNIVERSITY · 1988 · $183,529

## Abstract

The purpose of the research is to characterize a sharp thermotropic
transition that has been demonstrated to occur in the membranes of
mammalian cells.  The effect of heating on plasma and nuclear membranes
will be studied using a variety of biochemical, biophysical, and
immunological techniques.  Order parameters are to be obtained using spin
label electron paramagnetic resonance techniques.  Selected labels and
fluorescent probes will characterize specific membrane regions and
components.  Values of lateral diffusion coefficients will be obtained by
photo-bleaching experiments.  Distribution, density and lateral mobility of
H-2 and HLA antigens is to be determined using radiolabeled and fluorescent
monoclonal antibodies.  The effect of heating on cholesterol content of
plasma membranes will be related to antibody binding.  The information to
be obtained from this research should suggest new approaches in clinical
hyperthermia, suggest ways of improving drug delivery to solid tumors in
chemotherapy, and to perhaps provide a rational, cellular basis for
heat-immunotherapy.

## Key facts

- **NIH application ID:** 3170669
- **Project number:** 5R01CA032827-06
- **Recipient organization:** STANFORD UNIVERSITY
- **SAM.gov UEI:** HJD6G4D6TJY5
- **Principal Investigator:** GEORGE M HAHN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $183,529
- **Award type:** 5
- **Project period:** 1982-08-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170669

## Citation

> US National Institutes of Health, RePORTER application 3170669, HYPERTHERMIA, RADIATION, MEMBRANE STRUCTURE AND FUNCTION (5R01CA032827-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170669. Licensed CC0.

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