# RADIONUCLIDES: RADIATION DETECTION AND QUANTIFICATION

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1989 · $287,753

## Abstract

The long term goal of this proposed work is to optimize the performance and
functionality of SPRINT II with the aim of being better able to study both
static and dynamic processes quantitatively.  The aim is to extend the
capabilities of SPECT to functional imaging.  To accomplish this requires
improvements in intrinsic detector resolution and linearity, refinement in
aperture geometry, more accurate image reconstruction algorithms, and a
better understanding of the nature of information transfer in the
tomographic imaging process.

Detector improvements will be accomplished by means of Monte Carlo modeling
and by extending the 1-dimensional maximum likelihood position estimation
to 2-dimensions.

Optimum aperture design will include a study of mutual information and
analysis of variance and bias in reconstructed images.

Efficient reconstruction algorithms will be developed for the non-standard
sampling geometry of SPRINT II which will include attenuation and scatter
correction.  Finally, application of mutual information will be extended to
detection and discrimination tasks.

## Key facts

- **NIH application ID:** 3170691
- **Project number:** 2R01CA032846-19
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** WILLIAM L ROGERS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $287,753
- **Award type:** 2
- **Project period:** 1983-04-01 → 1991-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170691

## Citation

> US National Institutes of Health, RePORTER application 3170691, RADIONUCLIDES: RADIATION DETECTION AND QUANTIFICATION (2R01CA032846-19). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170691. Licensed CC0.

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