# RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1990 · $236,267

## Abstract

Tumor imaging will be advanced by studying the uptake of particles
in malignant tumors.  The pharmacodynamics of concentrated
emulsions of perfluorooctylbromide (PFOB) will be determined by
measuring the distribution, metabolism and elimination patterns of
PFOB in tumors, liver and spleen in mice, rats and rabbits.  This
information will be used to determine the optimal timing and dose
for imaging.  Concentrations of PFOB will be measured by gas
chromatography and X-ray fluorescent spectroscopy.  Distribution
patterns will be assessed by low voltage X-ray.  CT scans or MRI.
Microscopic examination will be used to determine localization of
emulsion particles.

Methods to facilitate the uptake of PFOB in the tumor macrophages
will be explored by breathing the tumored mice on increased
concentrations of O2 following administration of PFOB emulsion
which is also an excellent oxygen delivery system.  Other response
modifying agents will also be used such as cosurfactants,
fluorosurfactants, hormones, monokines and other compounds in order
to increase tumor concentrations of PFOB.  The tolerance of  these
modified emulsions will be measured by standard toxicological
techniques.

Additional investigations will be performed to study the mechanisms
by which the tumor macrophage population and function is altered
by the administration of fluorochemical emulsions.  The number of
phagocyte cells in the proliferation phase will be estimated by
labeling cells with tritiated thymidine.  The source of the rapidly
proliferating cells will be studied by radiation therapy with
selective shielding of the tumor during whole body radiation and
shielding of the body during tumor radiation.

## Key facts

- **NIH application ID:** 3170724
- **Project number:** 5R01CA032857-11
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** DAVID M LONG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $236,267
- **Award type:** 5
- **Project period:** 1979-01-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170724

## Citation

> US National Institutes of Health, RePORTER application 3170724, RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY (5R01CA032857-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170724. Licensed CC0.

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