# ANALOG CODED SYSTEMS FOR POSITRON TOMOGRAPHY

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 1992 · $360,987

## Abstract

Positron imaging has clearly demonstrated its potential for the study and
diagnosis of functional disease.  However the future of positron imaging
will depend on the development of positron emission tomography (PET) with
higher sensitivity and resolution.  To achieve this goal, PCR-II, a
cylindrically shaped analog coded positron tomograph, has been designed and
is in the final stages of construction.  The instrument will approach the
fundamental limits of sensitivity and resolution of positron detection.

Algorithms have been developed for three-dimensional reconstruction of data
from PCR-II.  Algorithms for Fourier space reconstruction are available as
well as algorithms for conventional filtered backprojection.  A Monte-Carlo
simulation code has been used to assist in this process.

On initial completion of PCR-II, the instrument will undergo an intensive
program of physical study including phantom imaging.  Animal studies will
be carried out to determine the performance of the instrument and to
demonstrate the biological significance of high resolution, quantitative
PET imaging.  Biological imaging will lead to ultimate clinical research
application.  Biological and clinical applications will be carried out with
collaboration at MGH and elsewhere.  The refinement of PCR-II hardware and
software will continue, however, over the three year period.

Studies using PCR-I in animal models will continue until PCR-II is fully
operational.  These collaborative projects will involve a number of other
research groups.

Following initial study of PCR-II, attention will be given to approaches to
simplify construction and reduce electronic complexity.

## Key facts

- **NIH application ID:** 3170750
- **Project number:** 5R01CA032873-12
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **SAM.gov UEI:** FLJ7DQKLL226
- **Principal Investigator:** GORDON L BROWNELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $360,987
- **Award type:** 5
- **Project period:** 1981-08-01 → 1993-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170750

## Citation

> US National Institutes of Health, RePORTER application 3170750, ANALOG CODED SYSTEMS FOR POSITRON TOMOGRAPHY (5R01CA032873-12). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170750. Licensed CC0.

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