# CANCER PAIN--PHARMACOKINETIC CORRELATES OF ANALGESIA

> **NIH NIH R01** · SLOAN-KETTERING INST CAN RESEARCH · 1993 · $287,407

## Abstract

The major objectives of this proposal are to better understand the
theoretical and practical aspects of the clinical pharmacology of opioid
analgesics in humans.  This knowledge will facilitate the development of
scientifically based guidelines for the use of these drugs in pain
management.  We have developed analgesic assay methods for assessing pain
and opioid side effects, specific and sensitive analytical methods to
quantitate opioids and their metabolites in biofluids and techniques of
PK-PD analysis that relate drug concentration to opioid effects.  We will
now extend this approach and apply PK-PD analysis to the elucidation of
morphine pharmacology, the improved administration of common (e.g. oral)
and novel (transdermal) opioid therapies and investigation of tolerance
and cross-tolerance.  We also plan to study the steady-state
concentrations of morphine and its metabolites in children as well as
adults with hepatic and renal dysfunction as well as adverse effects.
This information will provide quantitative data to substantiate or refute
clinical dosing guidelines and will provide information about effect of
age on drug disposition.

## Key facts

- **NIH application ID:** 3170763
- **Project number:** 2R01CA032897-11
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **SAM.gov UEI:** KUKXRCZ6NZC2
- **Principal Investigator:** KATHLEEN M. FOLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $287,407
- **Award type:** 2
- **Project period:** 1983-01-01 → 1996-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170763

## Citation

> US National Institutes of Health, RePORTER application 3170763, CANCER PAIN--PHARMACOKINETIC CORRELATES OF ANALGESIA (2R01CA032897-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3170763. Licensed CC0.

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