# CANCER PAIN--PHARMACOKINETIC CORRELATES OF ANALGESIA

> **NIH NIH R01** · SLOAN-KETTERING INST CAN RESEARCH · 1992 · $586,857

## Abstract

The major objectives of this proposal are to better understand the
theoretical and practical aspects of the clinical pharmacology of
opioid analgesics in human.  Such knowledge will allow for the
development of scientifically based guidelines for the use of these
drugs in the management of acute and chronic pain.  Our previous
studies have demonstrated the necessity and utility of
pharmacokinetic pharmacodynamic models in clinical analgesic
studies.  The major areas for study will be to measure the active
metabolites of morphine, specifically morphine-6-glucuronide,-
glucuronide, following oral, parenteral and intrathecal routes to
assess its contribution to the analgesic and side effects of
morphine.  Using our pharmacokinetic-pharmacodynamic model, we will
study the pharmacological and psychological factors that relate to
patient controlled analgesiac (PCA) and repetitive oral dosing on
a fixed or prn schedule.  Similarly, we hope to quantitatively
define the development of tolerance to the pharmacodynamic effects
of opioids during repetitive losing for pain management.  Opioid
analgesics administered by novel routes offer special advantages
to the cancer patient with pain.  We plan to continue to study the
pharmacokinetic aspects of sublingual, subcutaneous, and
intrathecal administration and to use a sheep model to further
assess the pharmacokinetics of cerebrospinal fluid drug
distribution.  We have developed a methodology to assess pain in
children and we will study the sensitivity of this method to define
the relative potency of analgesics in children.  Comparative
studies of heroin and hydromorphone have been designed to assess
the relative merits of each of these drugs in acute and chronic
cancer pain management.  These studies will be performed in
patients with acute and chronic pain of cancer who represent an
appropriate experimental group for the study of pain in humans.

## Key facts

- **NIH application ID:** 3170771
- **Project number:** 7R01CA032897-10
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **SAM.gov UEI:** KUKXRCZ6NZC2
- **Principal Investigator:** KATHLEEN M. FOLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $586,857
- **Award type:** 7
- **Project period:** 1983-01-01 → 1992-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170771

## Citation

> US National Institutes of Health, RePORTER application 3170771, CANCER PAIN--PHARMACOKINETIC CORRELATES OF ANALGESIA (7R01CA032897-10). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3170771. Licensed CC0.

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