# BIOSTATISTICAL METHODS FOR CARCINOGENICITY EXPERIMENTS

> **NIH NIH R01** · HARVARD MEDICAL SCHOOL · 1988 · $79,362

## Abstract

The application proposes a continuation of statistical research
into problems arising in laboratory experiments designed to assess
the potential hazards of food additives, drugs, cosmetics, and
other chemicals.  The long-term objectives are to develop
methodologies for designing and interpreting these experiments.
The specific problems to be addressed in the current proposal
include:  (1) Biases and efficiencies of existing methods for
assessing carcinogenicity; (2) Theoretical and empirical studies of
cause-of-death data; (3) Use of pathology information in analysis
of tumor onset; (4) Adaptive sacrifice methods; and (5) Methods
for rodent teratology experiments.  Each of these topics will
involve theoretical considerations, as well as extensive
exploratory analyses of the ED01 experiment and other data sets.

## Key facts

- **NIH application ID:** 3170971
- **Project number:** 2R01CA033041-07
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **SAM.gov UEI:** JDLVAVGYJQ21
- **Principal Investigator:** Stephen W. Lagakos
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $79,362
- **Award type:** 2
- **Project period:** 1982-07-01 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3170971

## Citation

> US National Institutes of Health, RePORTER application 3170971, BIOSTATISTICAL METHODS FOR CARCINOGENICITY EXPERIMENTS (2R01CA033041-07). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3170971. Licensed CC0.

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