# RECOMBINANT INBRED STRAINS AND CANCER

> **NIH NIH R01** · JACKSON LABORATORY · 1987 · $159,824

## Abstract

Our objectives are the development and genetic characterization of sets of
recombinant inbred (RI) strains of mice, which are derived from the crosses
of pairs of inbred (progenitor) strains.  These RI strains are being used
to genetically analyze numerous differences between the progenitors,
including lymphoma susceptibility.  The RI strains are being typed for
newly discovered polymorphisms, which serve as genetic markers for the
analysis of inheritance of complex traits such as susceptibility to
lymphoma and autoimmunity.  The lymphoma incidence and latency has been
determined for half of the 26 AKXD RI strains which were inbred from the
cross of the high lymphoma strain AKR/J with the low lymphoma DBA/2J
strain.  Mice from the remaining ADXD strains are currently being aged to
determine their predisposition to lymphoma.  It is evident that none of the
13 strains are as lymphoma-prone as are AKR/J progenitor strain mice.
Although some strains have quite high incidences of lymphoma, the age of
onset is later.  Similarly, although DBA/2J is a lymphoma-resistant and
long-lived strain (average lifespan greater than 700 days), none of the 13
AKXD RI strains appears to have moderate incidences of lymphomas,
suggesting that various combinations of genes may interact so as to confer
moderate susceptibility to lymphoma.  Specific loci which are expected to
contribute to AKR/J susceptibility include the ecotropic virogenes Akv-1
and Akv-4, the H-2 haplotype, and the Rmcf locus which controls the spread
of MCF-type viruses.  The AKXD strains have been characterized with respect
to all of these loci.  The importance of the Akv virogenes to AKR lymphoma
is evident in this material as in previous studies.  The most common tumor
types were lymphocytic lymphomas and follicle center-cell lymphomas.  We
are attempting to transfer the xenotropic virus non-inducibility trait of
SWR/J (controlled by the Bxv-1 locus) to the AKR/J background.  We are
using the visible mutation ichthyosis (ic) to select for the Bxv-1 locus
indirectly.  If successful, we will be able to evaluate the influence of
the Bxv-1 locus on susceptibility to lymphoma in the AKR/J mouse strain.
RI strains have been used to map restriction-fragment length polymorphisms
detected with a serum amyloid A cDNA probe in chromosome 7. Several serum
amyloid A genes are evidently located in a tight cluster.  (Q)

## Key facts

- **NIH application ID:** 3171026
- **Project number:** 5R01CA033093-06
- **Recipient organization:** JACKSON LABORATORY
- **SAM.gov UEI:** XR6LMXNKDJJ1
- **Principal Investigator:** BENJAMIN A TAYLOR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $159,824
- **Award type:** 5
- **Project period:** 1982-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171026

## Citation

> US National Institutes of Health, RePORTER application 3171026, RECOMBINANT INBRED STRAINS AND CANCER (5R01CA033093-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171026. Licensed CC0.

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