# NEUROPSYCHOLOGICAL ASSESSMENT OF CHILDREN WITH CANCER

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1988 · $105,679

## Abstract

Advances in pediatric oncology have provided for an increasingly positive
prognosis for childhood leukemia.  Initial concern for survival is now
being augmented by concern about the enuropsychological sequelae of
treatment.

The aim of the proposed project is to evaluate the longitudinal effects of
prophylactic CNS Therapy, intensive CNS Therapy, and no CNS Therapy
(control group for the cancer experience per se) on the neuropsychological
status of pediatric oncology patients.  The immediate and long-term effects
of Vincristine and high-dose Cis-platinum on neuropsychological functioning
relation to medication schedules and dosages will be assessed as well.  A
test battery developed by a neuropsychologist expressly for the evaluation
will be administered at diagnosis and at yearly intervals.  The
neuropsychology battery assesses the following skills:  intelligence,
visual-motor and constructional skills, fine-motor skills, spatial-tactile
skills, language ability, memory and learning, and academic achievement.
Additional information from CT scans, a parents' behavior checklist, and a
teacher's school report will supplement the primary data base.  The
performance of both Spanish and English speaking patients will be evaluated.

Data analysis will test the hypothesis that consistent progressive patterns
of disturbances in the child's neuropsychological functioning are
associated with the CNS treatment under investigation.  Separate data
analysis procedures will provide an estimate of how, when and to what
degree a particular child is affected, and the degree to which a particular
CNS therapy may place the child at developmental risk with respect to
established norms.  This information will not only provide the oncologist
with pertinent information, but will enable the patient to be counseled for
appropriate academic placement.

## Key facts

- **NIH application ID:** 3171036
- **Project number:** 5R01CA033097-06
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **SAM.gov UEI:** S3GMKS8ELA16
- **Principal Investigator:** DONNA R COPELAND
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $105,679
- **Award type:** 5
- **Project period:** 1983-02-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171036

## Citation

> US National Institutes of Health, RePORTER application 3171036, NEUROPSYCHOLOGICAL ASSESSMENT OF CHILDREN WITH CANCER (5R01CA033097-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171036. Licensed CC0.

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